Protein: ORF9b protein database
Organism Severe acute respiratory syndrome coronavirus (SARS-CoV) Status Reviewed-Annotation score:-Experimental evidence at protein leveli
Plays a role in the inhibition of host innate immune response by targeting the mitochondrial-associated adapter MAVS. Mechanistically, usurps the E3 ligase ITCH to trigger the degradation of MAVS, TRAF3, and TRAF6. In addition, causes mitochondrial elongation by triggering ubiquitination and proteasomal degradation of dynamin-like protein 1/DNM1L.1 Publication
The gene encoding this protein is included within the N gene (alternative ORF).
GO – Molecular functioni
GO – Biological processi
|Biological process||Host-virus interaction, Inhibition of host innate immune response by virus, Inhibition of host MAVS by virus, Inhibition of host RLR pathway by virus, Viral immunoevasion|
For In-depth Information of ORF-9b Protein: https://www.uniprot.org/uniprot/P59636