UniProtKB – P59636 (ORF9B_SARS)

Protein: ORF9b protein database

Gene: 9b

Organism Severe acute respiratory syndrome coronavirus (SARS-CoV) Status Reviewed-Annotation score:-Experimental evidence at protein leveli


Plays a role in the inhibition of host innate immune response by targeting the mitochondrial-associated adapter MAVS. Mechanistically, usurps the E3 ligase ITCH to trigger the degradation of MAVS, TRAF3, and TRAF6. In addition, causes mitochondrial elongation by triggering ubiquitination and proteasomal degradation of dynamin-like protein 1/DNM1L.1 Publication


The gene encoding this protein is included within the N gene (alternative ORF).

GO – Molecular functioni

GO – Biological processi


Biological processHost-virus interactionInhibition of host innate immune response by virusInhibition of host MAVS by virusInhibition of host RLR pathway by virusViral immunoevasion

For In-depth Information of ORF-9b Protein: https://www.uniprot.org/uniprot/P59636

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