Authors: Posted on January 13, 2022 by Jesse Santiano, M.D.
The SARS-CoV-2 virus has four structural proteins. The spike, membrane, envelop, and nucleocapsid proteins. The spike protein protrudes from the middle of the coronavirus and attaches to the ACE2 receptor of cells to start the process of cell entry, replication, and infection. The two major parts of the spike protein are the S1 and S2 subunit. The S1 has the receptor-binding domain.
For easier reading, this review starts with what happens after the COVID jabs, soluble spike proteins, and what it takes to have a normal blood vessel. Then I will enumerate how the spike protein damages the body.
What happens after the COVID shots?
COVID vaccination aims to produce an immune response against the spike protein in the form of neutralizing antibodies so that in future SARS-CoV-2 exposures, COVID-19 will be prevented.
The injected messenger RNA provides instructions to the cells on making the spike proteins. Once the spike protein is produced, it migrates to the outside of the cell to be anchored on the cells’ outer surface, where the immune system will recognize it and develop an immune response to it. (antibodies, T cells, B cells).
Soluble spike proteins
Ideally, the whole spike protein should stay attached to the outside of the cells. Sometimes incomplete spike proteins are produced in the form of spike peptides. As shown below, they are also presented to the immune system by cells outside the surface with an anchoring protein called the Major Histocompatibility Complex (MHC).
Anchoring to the cells is critical because once the spike protein or its pieces in the form of peptides become soluble or float in the bloodstream, they induce inflammation and clot formation in the arteries and capillaries. Scientists have found several ways that it happens.
The second is that errors can happen while RNA splicing occurs inside the nucleus. This results in variant spike proteins that are soluble. Soluble S1 subunits were observed among recipients of the Moderna shots.
You can read more about it in this article: SARS-CoV-2 spike proteins detected in the plasma following Moderna shots.
Third, are exosomes released from cells containing MHCs with the spike proteins.  T-cells can interact with the spike proteins in the exosomes and cause inflammation . Immunogenic spike proteins inside exosomes were demonstrated after Pfizer injection.
The normal blood vessel
All organs in the body need an adequate blood supply, and blood vessels have to be in pristine working conditions for that to happen. They should be distensible to allow greater blood flow during exertion, smooth inside to prevent blood clot formation, and have working mechanisms to repair themselves and dissolve blood clots that may form.
All that work falls on the endothelial cells that line the inner wall of the blood vessels, andI talked about them at The Magical Endothelium. Any injury to the endothelium can elicit an inflammatory response and clot formation leading to organ dysfunctions like heart attacks, strokes, and deaths.
Blood clots always start small, and once they develop, they initiate a chain reaction that promotes a more extensive clot. The good thing is that the body can do fibrinolysis, a built-in mechanism to dissolve clots.
13 ways Spike Proteins cause disease
The following are how the spike proteins and their S1 subunit can cause damage. They can work together and have four results, inflammation, thrombosis or clot formation, auto-immunity, and amyloid formation.
Inflammation and thrombosis
The spike protein triggers cell signaling events that promote pulmonary vascular remodeling and pulmonary arterial hypertension (PAH), and other cardiovascular complications Source: Suzuki and Gychka. Vaccines 2
Spike proteins cause vascular leaks by degrading the barrier of the endothelium.  The leak may explain the proliferation of lymphocytes seen by German pathologists in the organs of deceased patients who died after the shots.
Spike proteins affect the cardiac pericytes, the cells that “supervise” the endothelial cells responsible for maintaining the smoothness of the blood vessels. . Study shows spike proteins affect cardiac pericytes and explain why soccer players collapse
The S1 produces blood clots resistant to the body’s fibrinolysis and hospital clot-buster medications . That’s why some have their limbs amputated after the shots. One woman had both legs and hands amputated. There’s a list here.
- The S1 Proteins can persist in CD16+ Monocytes up to 15 Months Post-Infection and vaccination to induce chronic inflammation. This explains the symptoms of the Long COVID Syndrome. 
Amyloids formation and interaction
- Amyloids are fibrillar proteins. They are most commonly associated with neurodegenerative diseases like dementia. However, they can also form in the heart and lungs and make them rigid and form blood clots resistant to dissolution.  The SARS-CoV-2 spike protein can form amyloids seen in lung, blood, and nervous system disorders
- The S1 protein contains heparin-binding sites that attract amyloids to initiate amyloid protein aggregation. Amyloid formation leads to neurodegeneration like Parkinson’s Disease, Alzheimer’s’ disease, and Frontal lobe dementia. 
12. Molecular mimicry happens if protein sequences in the spike protein and peptides have similarities to human proteins. Antibodies made for those viral proteins may also attack the host proteins..
This leads to several autoimmune diseases like immune thrombocytopenia (low platelet counts) , autoimmune liver diseases, Guillain-Barré syndrome, IgA nephropathy, rheumatoid arthritis, and systemic lupus erythematosus
Cancer and Immune Deficiency
- Spike proteins impair DNA damage repair and result in ineffective antibodies and damaged tumor-suppressor genes like the BRCA1 and 53BP1 that lead to cancers. BRCA1 damage is associated with breast, ovarian, and prostate cancers.
53BP1 loss of function in tumor tissues is elated to tumor occurrence, progression, and poor prognosis in human malignancies.
The disease-causing part of the SARS-CoV-2 virus is the spike protein, and it is present in COVID-19 and the COVID injections. Prevention and early treatment are possible for COVID-19. Once you have the shot, there is no way to control the spike protein.
It is unclear why not all have the adverse effects or die. What is sure is that there are over one million reported adverse effects on VAERS, and more than one hundred thousand have been killed. Vaccine-induced deaths in the U.S. and Europe are way higher than the VAERS reports!
- Indiana life insurance CEO says deaths are up 40% among people ages 18-64
- CDC data shows higher deaths from 25-54 years old in 2021 compared to 2018-2020
- 145 countries with higher COVID-19 cases and deaths after the COVID shots
This list is not all-inclusive, and I probably missed some. Indeed, more will be discovered in the future, and I don’t want my body to find out. Do you?
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- Blood Vessel Damaging Proteins of the SARS-CoV-2
- Cerebral Thrombosis after the Pfizer Covid-19 Vaccine
- The High Risk of Deadly Brain Clots in the J & J COVID Vaccine
- This Study shows a Ten-Fold Risk of Developing Blood Clots after the COVID Vaccines.
- You got the COVID shot and found that others developed blood clots. Now what?
- Platelet Changes Causes Blood Clots in COVID-19
- Unidentified Foreign Bodies in the Vaccines Form Clots
- Retinal complications after COVID shots
- U.K. Study of COVID-19 shots and Excess Rates of Guillain-Barré Syndrome
- mRNA Vaccination Increases the Risk of Acute Coronary Syndrome
- German Analysis: The Higher the Vaccination Rate, the Higher the Excess Mortality
- Anti-Idiotype Antibodies against the Spike Proteins may Explain Myocarditis
- Rijkers GT, Weterings N, Obregon-Henao A, et al. Antigen Presentation of mRNA-Based and Virus-Vectored SARS-CoV-2 Vaccines. Vaccines (Basel). 2021;9(8):848. Published 2021 Aug 3. doi:10.3390/vaccines9080848
- Kowarz E, Krutzke L, Reis J, et al. “Vaccine-Induced Covid-19 Mimicry” Syndrome: Splice reactions within the SARS-CoV-2 Spike open reading frame result in Spike protein variants that may cause thromboembolic events in patients immunized with vector-based vaccines. Research Square; 2021. DOI: 10.21203/rs.3.rs-558954/v1
- Ogata AF. et al. Circulating SARS-CoV-2 Vaccine Antigen Detected in the Plasma of mRNA-1273 Vaccine Recipients [published online ahead of print, 2021 May 20]. Clin Infect Dis. 2021;ciab465. doi:10.1093/cid/ciab465
- Hervier B, Ribon M, Tarantino N, Mussard J, Breckler M, Vieillard V, Amoura Z, Steinle A, Klein R, Kötter I, Decker P. Increased Concentrations of Circulating Soluble MHC Class I-Related Chain A (sMICA) and sMICB and Modulation of Plasma Membrane MICA Expression: Potential Mechanisms and Correlation With Natural Killer Cell Activity in Systemic Lupus Erythematosus. Front Immunol. 2021 May 3;12:633658. doi: 10.3389/fimmu.2021.633658. PMID: 34012432; PMCID: PMC8126610.
- Salih, Helmut & Goehlsdorf, Dennis & Steinle, Alexander. (2006). Salih HR, Goehlsdorf D, Steinle A. Release of MICB molecules by tumor cells: mechanism and soluble MICB in sera of cancer patients. Hum Immunol 67: 188-195. Human immunology. 67. 188-95. 10.1016/j.humimm.2006.02.008.
- Edgar JR. Q&A: What are exosomes, exactly?. BMC Biol. 2016;14:46. Published 2016 Jun 13. doi:10.1186/s12915-016-0268-z
- Raposo G, Nijman HW, Stoorvogel W, Liejendekker R, Harding CV, Melief CJ, Geuze HJ. B lymphocytes secrete antigen-presenting vesicles. J Exp Med. 1996 Mar 1;183(3):1161-72. doi: 10.1084/jem.183.3.1161. PMID: 8642258; PMCID: PMC2192324.
- Bansal et al. Cutting Edge: Circulating Exosomes with COVID Spike Protein Are Induced by BNT162b2 (Pfizer–BioNTech) Vaccination prior to Development of Antibodies: A Novel Mechanism for Immune Activation by mRNA Vaccines. J Immunol November 15, 2021, 207 (10) 2405-2410
- Nuovo, G.J. et al. (2021) Endothelial cell damage is the central part of COVID-19 and a mouse model induced by injection of the S1 subunit of the spike protein. Ann. Diagn. Pathol. 51, 151682, https://doi.org/10.1016/j.anndiagpath.2020.151682
- Gu, T. et al. (2020) Cytokine signature induced by SARS-CoV-2 spike protein in a mouse model. Front. Immunol. 11, 621441,
- Aboudounya MM, Heads RJ. COVID-19 and Toll-Like Receptor 4 (TLR4): SARS-CoV-2 May Bind and Activate TLR4 to Increase ACE2 Expression, Facilitating Entry and Causing Hyperinflammation. Mediators Inflamm. 2021 Jan 14;2021:8874339. doi: 10.1155/2021/8874339. PMID: 33505220; PMCID: PMC7811571.
- Shirato K, Kizaki T. SARS-CoV-2 spike protein S1 subunit induces pro-inflammatory responses via toll-like receptor 4 signaling in murine and human macrophages. Heliyon. 2021 Feb 2;7(2):e06187. doi: 10.1016/j.heliyon.2021.e06187. PMID: 33644468; PMCID: PMC7887388. https://pubmed.ncbi.nlm.nih.gov/33644468/
- Suzuki YJ, et al. SARS-CoV-2 Spike Protein Elicits Cell Signaling in Human Host Cells: Implications for Possible Consequences of COVID-19 Vaccines. Vaccines (Basel). 2021;9(1):36. Published 2021 Jan 11. doi:10.3390/vaccines9010036
- Cao, X. et al. (2021) Spike protein of SARS-CoV-2 activates macrophages and contributes to induction of acute lung inflammation in male mice. FASEB J. 35, e21801
- Biering et al. SARS-CoV-2 Spike triggers barrier dysfunction and vascular leak via integrins and TGF-β signaling. bioRxiv 2021.12.10.472112
- Avolio E et al. The SARS-CoV-2 Spike protein disrupts human cardiac pericytes function through CD147 receptor-mediated signaling: a potential non-infective mechanism of COVID-19 microvascular disease. Clin Sci (Lond). 2021 Dec 22;135(24):2667-2689. doi: 10.1042/CS20210735. PMID: 34807265; PMCID: PMC8674568.
- Lei, Y. et al. SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE 2. Circulation Research. 2021;128:1323–1326
- Grobbelaar, L.M. et al. (2021) SARS-CoV-2 spike protein S1 induces fibrin(ogen) resistant to fibrinolysis: implications for microclot formation in COVID-19. Biosci. Rep. 41 (8)
- Patterson B. et al. Persistence of SARS CoV-2 S1 Protein in CD16+ Monocytes in Post-Acute Sequelae of COVID-19 (PASC) Up to 15 Months Post-Infection.bioRxiv 2021.06.25.449905
- Yu J, Yuan X, Chen H, Chaturvedi S, Braunstein EM, Brodsky RA. Direct activation of the alternative complement pathway by SARS-CoV-2 spike proteins is blocked by factor D inhibition. Blood. 2020.
- Nyström et al. Amyloidogenesis of SARS-CoV-2 Spike Protein. bioRxiv 2021.12.16.472920.
- Idrees D, Kumar V. SARS-CoV-2 spike protein interactions with amyloidogenic proteins: Potential clues to neurodegeneration. Biochem Biophys Res Commun. 2021 May 21;554:94-98. doi: 10.1016/j.bbrc.2021.03.100. Epub 2021 Mar 24. PMID: 33789211; PMCID: PMC7988450
- Nunez-Castilla, J et al. Spike mimicry of thrombopoietin may induce thrombocytopenia in COVID-19. bioRxiv 2021.08.10.455737
- Ehrenfeld M et al. Covid-19 and autoimmunity. Autoimmun Rev. 2020;19:102597.
- Kanduc D, Shoenfeld Y. On the molecular determinants of the SARS-CoV-2 attack. Clin Immunol. 2020;215.
- Vojdani A, Kharrazian D. Potential antigenic cross-reactivity between SARS-CoV-2 and human tissue with a possible link to an increase in autoimmune diseases. Clin Immunol. 2020;217:108480
- Chen Y, Xu Z, Wang P, Li XM, Shuai ZW, Ye DQ, Pan HF. New-onset autoimmune phenomena post-COVID-19 vaccination. Immunology. 2021 Dec 27. doi: 10.1111/imm.13443. Epub ahead of print. PMID: 34957554.
- Jiang H, Mei YF. SARS-CoV-2 Spike Impairs DNA Damage Repair and Inhibits V(D)J Recombination In Vitro. Viruses. 2021;13(10):2056. Published 2021 Oct 13. doi:10.3390/v13102056
- BRCA1 gene. Medline [website]
- Mirza-Aghazadeh-Attari M, et al. 53BP1: A key player of DNA damage response with critical functions in cancer. DNA Repair (Amst). 2019 Jan;73:110-119. doi: 10.1016/j.dnarep.2018.11.008. Epub 2018 Nov 20. PMID: 30497961.