US Covid-19 Breakthrough Infections-are-Uncommon Rising Considerably and D-19 Breakthrough Infections are Uncommon, Rising Considerably, and Sort of Okay

Authors: PETER WEBER 5:20 AM

The Biden administration is advising eight-month booster shots for Americans vaccinated with the Pfizer and Moderna COVID-19 vaccines because the Delta variant, which now accounts for about 98.8 percent of new U.S. infections, is a lot more contagious and the effectiveness of the vaccines appears to wane with time. 

“Fortunately,” the COVID-19 vaccines are “still holding at a high level” of protection from hospitalization and death, Surgeon General Vivek Murthy said Wednesday. “But our anticipation is that if the trajectory that we are seeing continues … we will likely see in the future an increase in breakthrough hospitalizations and breakthrough deaths” without boosters.

Even as the Delta variant surges, “COVID-19 breakthrough cases remain uncommon,” The Wall Street Journal reports, citing its own analysis of data from health departments in 44 states and Washington, D.C. In those states, about 0.1 percent of vaccinated residents got COVID between Jan. 1 and early August, the Journal found.

“This continues to be ‘a pandemic of the unvaccinated,'” but “breakthrough infections accounted for 12 percent to 24 percent of COVID-related hospitalizations” in seven states keeping detailed records, The New York Times reports, citing its analysis. Those breakthrough cases are mostly among older or immunocompromised adults — in Oregon, for example, the median age for a breakthrough-associated death is 83, and 74 percent of breakthrough cases nationwide are among people 65 and older, federal data show. 

The overall numbers remain small, but it’s pretty clear “the chances of a breakthrough infection have gone up considerably,” U.C. San Francisco’s Dr. Robert Wachter tells the Times. “Remember when the early vaccine studies came out, it was like nobody gets hospitalized, nobody dies,” he added. “That clearly is not true.”

“Let’s be real, here: Breakthrough infections are sort of okay,” Larry Corey, a virologist at Seattle’s Fred Hutchinson Cancer Research Center, tells the Journal. “You get infected and you have a cold, maybe an achy fever for 24 hours. But you don’t end up in the hospital, and you don’t end up with that 2.5 percent chance of dying once you are hospitalized.”

“All we’re really seeing, with vaccine breakthrough cases that come into the hospital, are people who are over 80 or have a compromised immune system,” adds Jorge Bernett, an infectious disease specialist with John Muir Health in Walnut Creek, California. “Basically everyone who is on a ventilator is unvaccinated.”

Resolving “Long-Haul COVID” and Vaccine Toxicity: Neutralizing the Spike Protein

Authors: Dr. Thomas E. Levy, MD, JD July 1, 2021

Although the mainstream media outlets might have you believe otherwise, the vaccines that continue to be administered for the COVID pandemic are emerging as substantial sources of morbidity and mortality themselves. While the degree to which these negative outcomes of the COVID vaccines can be debated, there is no question that enough disease and death have already occurred to warrant cessation of the administration of these vaccines until additional scientifically-based research can examine the balance between its now clear-cut side effects versus its potential (and still not yet clearly proven) ability to prevent new COVID infections.

Nevertheless, enough vaccinations have already been administered to warrant concern that a new “pandemic” of illness and death may well be emerging from the side effects that continue to be documented in steadily increasing numbers. The vaccine-induced “culprit” that is now receiving most of the attention and is the focus of much new research is the COVID virus fragment known as the spike protein. Its physiological impact appears to be doing far more harm than good (COVID antibody induction), and its manner of introduction appears to be fueling its ongoing replication with a continuing presence inside the body for an indefinite length of time.

The physical appearance of the COVID virus can been depicted as a central sphere of viral protein surrounded completely by spear-like appendages. Known as spike proteins, they are very analogous to the quills surrounding a porcupine. And just as the porcupine stabs its victim, these spike proteins penetrate into cell membranes throughout the body. After this penetration, protein-dissolving enzymes are activated, the cell membrane breaks down, the viral sphere enters the cytoplasm through this membrane breach, and the metabolism of the cell is subsequently “hijacked” to manufacture more viral particles. These spike proteins are the focus of a great deal of ongoing research examining vaccine side effects (Belouzard et al., 2012; Shang et al., 2020).The Spike Protein’s Toxic Effects in the Body The spike protein first attaches to ACE2 (angiotensin converting enzyme 2) receptors in the cell membranes (Pillay, 2020). This initial binding step is vital to triggering the subsequent sequence of events that brings the virus inside the cell. When this binding is blocked by competition or prompt enough displacement with an appropriate therapeutic agent, the virus cannot enter the cell, the infectious process is effectively stopped, and the immune defenses of the body are freed to mop up, metabolize, and eliminate the viral pathogens, or just the spike protein alone if free and no longer attached to a viral particle.Although ACE2 is found in many different cells throughout the body, it is especially noteworthy to realize that it is the initial target bound by coronavirus on the epithelial cells lining the airways after pathogen inhalation (Hoffmann et al., 2020). ACE2 expression (concentration) is also especially high on lung alveolar epithelial cells (Alifano et al., 2020). This cell membrane-bound virus can then begin the process that eventually results in the severe acute respiratory syndrome (SARS) seen in clinically-advanced COVID infections (Perrotta et al., 2020; Saponaro et al., 2020). The SARS presentation manifests most clearly when the degree of oxidative stress in the lungs is very elevated. This stage of COVID infection-related extreme oxidative stress is often referred to in the literature as a cytokine storm, and left unchecked this invariably leads to death (Hu et al., 2021).Increasing concern has focused on the continued presence of the spike protein in the blood by itself, unattached to a virion, following COVID vaccination. Supposedly intended to initiate an immune response to the entire virus particle, the spike protein injections are disseminating throughout the body rather than staying put in the upper arm at the vaccine site while the immune response to it evolves. Furthermore, it also appears that these circulating spike proteins can enter cells on their own and replicate themselves without attached virus particles. This not only wreaks havoc inside those cells, it helps to assure the indefinite presence of the spike protein throughout the body.It has also been suggested that large amounts of spike protein are just binding ACE2 receptors and not proceeding any further into the cell, effectively blocking or disabling normal ACE2 function in a given tissue. Additionally, when the spike protein binds a cell wall and “stops” there, the spike protein serves as a hapten (antigen) which can then initiate an autoimmune (antibody or antibody-like) response to the cell itself, rather than to the virus particle to which it is usually attached. Depending on the cell types to which such spike proteins bind, a wide variety of diseases with autoimmune qualities can result.Finally, another worrisome property of the spike protein which alone would be of great concern is that the spike protein itself appears to be highly toxic. This intrinsic toxicity, along with the apparent ability of the spike protein to replicate itself indefinitely within the cells it enters, probably represents the way in which the vaccine can inflict its worst long-term damage, as the production of this toxin can continue indefinitely without other external factors at play.In fact, the long-haul COVID syndrome likely represents a low-grade unresolved smoldering COVID infection with the same kind of spike protein persistence and clinical impact as is seen in many individuals after their COVID vaccinations (Mendelson et al., 2020; Aucott and Rebman, 2021; Raveendran, 2021).

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New Covid-19 Hospitalizations for 30- to 39-Year-Olds at Record Rate

Group largely avoided hospitals earlier in pandemic, but highly contagious Delta variant and lagging vaccination rates have changed health outcomes

Authors: By Melanie Evans and Taylor Umlauf

Hospitalizations of Covid-19 patients in their 30s have hit a new record, U.S. government data show, a sign of the toll that the highly contagious Delta variant is taking among the unvaccinated.

Thirty-somethings, who are in prime ages for work and parenting, had largely avoided hospital stays for Covid-19 during earlier phases of the pandemic because of their relative good health.

Yet the age group is seeing new Covid-19 hospital admissions increase during the recent Delta-driven surge, which doctors and epidemiologists attribute to the failure of large numbers of Americans to get vaccinated and their highly active lives.

The rate at which adults ages 30 to 39 are entering hospitals with Covid-19 reached about 2.5 per 100,000 people as of last Wednesday, according to the latest data from the U.S. Centers for Disease Control and Prevention and Department of Health and Human Services, up from the previous peak of roughly 2 per 100,000 people in early January.

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