COVID-19: A Mitochondrial Perspective

Authors: Pankaj Prasun 1

Coronavirus disease 2019 (COVID-19) is the worst public health crisis of the century. Although we have made tremendous progress in understanding the pathogenesis of this disease, a lot more remains to be learned. Mitochondria appear to be important in COVID-19 pathogenesis because of its role in innate antiviral immunity, as well as inflammation. This article examines pathogenesis of COVID-19 from a mitochondrial perspective and tries to answer some perplexing questions such as why the prognosis is so poor in those with obesity, metabolic syndrome, or type 2 diabetes. Although effective vaccines and antiviral drugs will be the ultimate solution to this crisis, a better understanding of disease mechanisms will open novel avenues for treatment and prevention.

For More Information: https://pubmed.ncbi.nlm.nih.gov/33872068/

Covid-19 Story Tip: Brain Fog, Fatigue, Dizziness … Post-COVID POTS Is Real

Authors: Tae Chung, M.D., assistant professor of physical medicine and rehabilitation and neurology at the Johns Hopkins University School of Medicine and director of the Johns Hopkins POTS Program

For almost one year, COVID-19 has impacted the world and taken the lives of many people. While some survivors have fully recovered from this illness, others are still experiencing lingering effects, such as chronic fatigue, brain fog, dizziness and increased heart rate. These survivors have been called “long-haulers,” and experts say some of the symptoms they are experiencing are thought to be caused by postural orthostatic tachycardia syndrome (POTS), a blood circulation disorder.

Some patients may, at first, believe their symptoms are “all in their head,” but Tae Chung, M.D., assistant professor of physical medicine and rehabilitation and neurology at the Johns Hopkins University School of Medicine and director of the Johns Hopkins POTS Program, says “POTS is very real.”

While experts are still researching the long-term side effects of COVID-19, it is clear to experts that some survivors are experiencing the classic signs of POTS as a result of their COVID-19 diagnosis.

Chung says POTS is related to autonomic nerve dysfunction. He explains that the autonomic nervous system is responsible for involuntary control of many of our body functions, such as sweating, pupil movement, bowel movement and blood flow. Many POTS symptoms are thought to be related to inadequate control of blood flow, causing brain fog and dizziness. Chung suspects that COVID-19 may be associated with chronic inflammation in the autonomic nervous system, causing POTS.

For More Information: https://www.hopkinsmedicine.org/news/newsroom/news-releases/covid-19-story-tip-brain-fog-fatigue-dizziness–post-covid-pots-is-real