Host immunological responses facilitate development of SARS-CoV-2 mutations in patients receiving monoclonal antibody treatments

Akshita Gupta,1,2 Angelina Konnova,1,2 Mathias Smet,1,2 Matilda Berkell,1,2 Alessia Savoldi,3 Matteo Morra,3 Vincent Van averbeke,1 Fien H.R. De Winter,1 Denise Peserico,4 Elisa Danese,4 An Hotterbeekx,1 Elda Righi,3 mAb ORCHESTRA working group,5 Pasquale De Nardo,3 Evelina Tacconelli,3 Surbhi Malhotra-Kumar,2 and Samir Kumar-Singh1,2 Journal of Clinical Investigation 10.1172/JCI166032 Abstract Background. The role of host immunity in emergence of evasive SARS-CoV-2 Spike mutations under therapeutic monoclonal antibody (mAb) pressure remains to be explored. Methods. In a prospective, […]

Unlocking life-threatening COVID-19 through two types of inborn errors of type I IFNs

Jean-Laurent Casanova1,2,3,4,5 and Mark S. Anderson6,7, Published February 1, 2023 – More infoView PDF Abstract Since 2003, rare inborn errors of human type I IFN immunity have been discovered, each underlying a few severe viral illnesses. Autoantibodies neutralizing type I IFNs due to rare inborn errors of autoimmune regulator (AIRE)–driven T cell tolerance were discovered in 2006, but not […]

Does the SARS-CoV-2 spike really have an Achilles heel?

Shiv Pillai, Published , 2023 – More infoView PDF , 10.1172/JCI168080 Abstract The continued emergence of SARS-CoV-2 variants and waning vaccine immunity are some of the factors that drive the continuing search for more effective treatment and prevention options for COVID-19. In this issue of the JCI, Changrob, et al. describe an anti-SARS-CoV-2 spike antibody, isolated from a […]

No evidence of durable trained immunity after two doses of adenovirus-vectored or mRNA COVID-19 vaccines

Natalie E. Stevens,1,2 Feargal J. Ryan,1,2 Nicole L. Messina,3,4 Stephen J. Blake,1,2 Todd S. Norton,1 Susie Germano,3 Jane James,1 Georgina L. Eden,1 Yee C. Tee,1,2 Miriam A. Lynn,1,2 Rochelle Botten,1 Simone E. Barry,5 Nigel Curtis,3,4 and David J. Lynn1,2 Published July 20, 2023 – September 1, 2023. Reference information: J Clin Invest. 2023;133(17):e171742. To the Editor: Trained immunity (TI) is defined as the long-term metabolic and epigenomic reprogramming of innate immune […]

Rare Skin Reactions after mRNA Vaccination, Similar to Jones–Mote Basophil Responses

Cutaneous Basophil Hypersensitivity Response after Skin-Test Antigen Injection. Philip W. Askenase, M.D., Yale University School of Medicine, New Haven, CT In a small group of recipients of messenger RNA (mRNA) vaccines against coronavirus disease 2019 (Covid-19), the occurrence of erythematous and indurated skin reactions has been reported at an average of 8 days after the […]

Why don’t most children get severely sick from COVID? Nose and immune response offer clues

By David Olson, October 23, 2023 10:50 Newsday Young children rarely get severely ill from COVID-19 because their immune systems seem to block the coronavirus from spreading beyond the nose, a new study suggests, and experts say kids’ response to the virus could help develop a more effective vaccine for people of all ages. Scientists long […]

The real data behind the new COVID vaccines the White House is pushing

By  Marty Makary and Tracy Beth Høeg Published Sep. 14, 2023 What if I told you one in 50 people who took a new medication had a “medically attended adverse event” and the manufacturer refused to disclose what exactly the complication was — would you take it? And what if the theoretical benefit was only transient, lasting […]

Cutting Edge: Circulating Exosomes with COVID Spike Protein Are Induced by BNT162b2 (Pfizer–BioNTech) Vaccination prior to Development of Antibodies: A Novel Mechanism for Immune Activation by mRNA Vaccines 

Sandhya Bansal; Sudhir Perincheri; Timothy Fleming; Christin Poulson;Brian Tiffany;Ross M. Bremner; Thalachallour Mohanakumar  J Immunol (2021) 207 (10): 2405–2410. Abstract Severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) causes severe acute respiratory syndrome. mRNA vaccines directed at the SARS-CoV-2 spike protein resulted in development of Abs and protective immunity. To determine the mechanism, we analyzed the kinetics […]

Potential molecular mechanisms of chronic fatigue in long haul COVID and other viral diseases

Carl Gunnar Gottschalk, Daniel Peterson, Jan Armstrong, Konstance Knox & Avik Roy  Infectious Agents and Cancer volume 18, Article number: 7 (2023) Cite this article, A Correction to this article was published on 24 April 2023 Abstract Historically, COVID-19 emerges as one of the most devastating diseases of humankind, which creates an unmanageable health crisis worldwide. Until now, this disease costs millions of lives and continues to paralyze […]

COVID-19 and emerging spinal cord complications: A systematic review

Ritwick Mondal,a Shramana Deb,b Gourav Shome,c Upasana Ganguly,a Durjoy Lahiri,a,d,⁎ and Julián Benito-Leóne,f,g,⁎⁎ Mult Scler Relat Disord. 2021 Jun; 51: 102917.Published online 2021 Mar 21. doi: 10.1016/j.msard.2021.102917 PMCID: PMC7981271 PMID: 33845350 Abstract Background : Spinal cord complications associated with coronavirus infectious disease of 2019 (COVID-19) are being widely reported. The purpose of this systematic review was to summarize so far available pieces of evidence documenting de novo novel severe […]