OC43 Membrane Protein Science

UniProtKB – Q01455 (VME1_CVHOC)


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Membrane protein

Gene

M

OrganismHuman coronavirus OC43 (HCoV-OC43)StatusReviewed-Annotation score:-Experimental evidence at protein leveli

Functioni

Component of the viral envelope that plays a central role in virus morphogenesis and assembly via its interactions with other viral proteins.UniRule annotation

GO – Molecular functioni

Complete GO annotation on QuickGO …

GO – Biological processi

Complete GO annotation on QuickGO …

Keywordsi

Biological processHost-virus interactionViral immunoevasion

Names & Taxonomyi

Protein namesiRecommended name:Membrane proteinUniRule annotationShort name:M proteinUniRule annotationAlternative name(s):E1 glycoproteinUniRule annotationMatrix glycoproteinUniRule annotationMembrane glycoproteinUniRule annotation
Gene namesiName:MUniRule annotationORF Names:6
OrganismiHuman coronavirus OC43 (HCoV-OC43)
Taxonomic identifieri31631 [NCBI]
Taxonomic lineageiViruses › Riboviria › Orthornavirae › Pisuviricota › Pisoniviricetes › Nidovirales › Cornidovirineae › Coronaviridae › Orthocoronavirinae › Betacoronavirus › Embecovirus › 
Virus hostiHomo sapiens (Human) [TaxID: 9606]
ProteomesiUP000180344 Componenti: GenomeUP000100580 Componenti: GenomeUP000007552 Componenti: Genome

Subcellular locationi

For All Information on This Protein: https://www.uniprot.org/uniprot/Q01455

Human coronavirus OC43 nucleocapsid protein binds microRNA 9 and potentiates NF-κB activation

Authors: Frances W Lai 1Kyle B StephensonJames MahonyBrian D Lichty

Abstract

The human coronavirus OC43 is a major contributor to the common cold worldwide, though due to its low mortality rate, little research has focused on this human pathogen. The nucleocapsid is an essential structural protein with conserved functions across the coronavirus family. While a multitude of studies have examined nucleocapsid function, none have described the effects of OC43 nucleocapsid on the transcription factor NF-κB. We report that the nucleocapsid protein of OC43 causes potentiation of NF-κB activation. This prolonged activation is the direct result of the ability of the nucleocapsid to bind RNA, specifically microRNA 9 (miR-9), which is a negative regulator of NF-κB. This previously undescribed interaction between virus and host is a potential mechanism of immune evasion in RNA viruses.

For More Information: https://pubmed.ncbi.nlm.nih.gov/24109243/